1388 Clinicopathological characteristics of fibrosing alopecia in a pattern distribution: A single-center, retrospective study

Fibrosing alopecia in a pattern distribution (FAPD) is characterized by patterned hair loss with signs of both AGA and lichen planopilaris (LPP). So far, most studies on FAPD are based Caucasians, only few have been Asian populations. For the first time, we evaluated clinical histopathological features 20 Chinese patients FAPD. Clinical, demographic datas were retrospectively collected from Huashan Hospital Fudan University. Seventeen females three males included (mean age 33 years), median Sinclair grade was 3. Two patient had frontal accentuation, five vertex thirteen diffuse centroparietal loss. Trichoscopic examinations showed diameter variability (20/20), perifollicular erythema (none 0/20, mild 7/20, moderate 11/20, severe 2/20), peripilar casts (perifollicular hyperkeratosis) 2/20, 12/20, 5/20, 1/20), follicular ostia (+ ± - 1/20). Histopathology revealed scarring lymphohistiocytic infiltration around infundibular region isthmus, increased frequency microinflammation signs, interface dermatitis, concentric lamellar fibrosis fibrosed tracts (follicular scars). Mean number mast cells 6.47 per high field. Our study might expand database case series for The uniqueness assessments, trichoscopic histopathology results indicate possibility racial difference. limitations our include collecting data one clinic, its retrospective design small sample size. It necessary to accumulate further cases other clinics assessments treatment therapeutic effect.